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. 1976 Nov 24;50(3):309-12.
doi: 10.1007/BF00426850.

Acquired preference for morphine but no d-amphetamine as a result of saccharine adulteration

S Y Hill, B J Powell

Acquired preference for morphine but no d-amphetamine as a result of saccharine adulteration

S Y Hill et al. Psychopharmacology (Berl). .

Abstract

Consumption of morphine sulfate and d-amphetamine was studied in two groups of rats. In a choice situation, preference for both drugs remained low after 46 days of drinking. In two additional groups morphine and d-amphetamine solutions were prepared with 1% saccharine. Morphine drinking was significantly increased by saccharine adulteration, whereas drinking of amphetamine solutions decreased. Addition of saccharine to morphine solutions increased drinking in more than a simple additive way. Saccharine facilitates the acquisition of drug-directed behavior. The slope of the acquisition trials for the morphine-saccharine group was significantly different from horizontal (O-slope) and significantly different from the slope found for the morphine without saccharine group.

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