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. 1976 Dec 24;194(4272):1439-41.
doi: 10.1126/science.827022.

Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland

T Sakakura, Y Nishizuka, C J Dawe

Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland

T Sakakura et al. Science. .

Abstract

Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.

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