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. 1976 Dec;34(6):626-34.
doi: 10.1038/bjc.1976.223.

Cytolytic effects of the complement cleavage product, C3a

J Ferluga, H U Schorlemmer, L C Baptista, A C Allison
Free PMC article

Cytolytic effects of the complement cleavage product, C3a

J Ferluga et al. Br J Cancer. 1976 Dec.
Free PMC article

Abstract

Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.

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