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. 1976 Jan 18;486(1):209-13.
doi: 10.1016/0005-2760(77)90086-8.

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187

W C Pickett, R L Jesse, P Cohen

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187

W C Pickett et al. Biochim Biophys Acta. .

Abstract

Phospholipase A2 activity in a suspension of intact platelets was induced by addition of a Ca2+-ionophore, A23187. This action of ionophore A23187 was enhanced by EGTA and inhibited by an excess of Ca2+ in the medium, findings which suggest that A23187 is able to mobilize intracellular Ca2+ for the latter's role as an essential cofactor for phospholipase A2 activity.

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