Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Oct;14(10):477-9.
doi: 10.1016/0167-5699(93)90259-n.

Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?

C K Borrebaeck  1 , A C Malmborg, M Ohlin
Affiliations

Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?

C K Borrebaeck et al. Immunol Today. 1993 Oct.

Abstract

Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.

PubMed Disclaimer

Publication types

LinkOut - more resources