Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Nov;5(3):230-5.
doi: 10.1038/ng1193-230.

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

N Galili  1 , R J Davis, W J Fredericks, S Mukhopadhyay, F J Rauscher 3rd, B S Emanuel, G Rovera, F G Barr
Affiliations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

N Galili et al. Nat Genet. 1993 Nov.

Erratum in

  • Nat Genet 1994 Feb;6(2):214

Abstract

We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma. The chromosome 13 gene (FKHR) is identified as a member of the fork head domain family of transcription factors characterized by a conserved DNA binding motif. Polymerase chain reaction analysis demonstrates that a 5'PAX3-3' FKHR chimaeric transcript is expressed in all eight alveolar rhabdomyosarcomas investigated. Immunoprecipitation experiments detect the predicted fusion protein. These findings indicate that the t(2;13) generates a potentially tumorigenic fusion transcription factor consisting of intact PAX3 DNA binding domains, a truncated fork head DNA binding domain and C-terminal FKHR regions.

PubMed Disclaimer

Publication types

MeSH terms

Associated data