Study of platelet aggregation in vivo i. Effect of bencyclan
- PMID: 827596
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Study of platelet aggregation in vivo i. Effect of bencyclan
J Med.
1976.
Abstract
A 20mu diameter pore size screen was inserted into an arterio-venous bypass system in heparinized stumptailed monkeys. ADP and serotonin injection resulted in aggregation of platelets on the screen and consecutive increase in pre-screen pressure and decrease in post-screen pressure. From these changes an "aggregation index" was calculated. Bencyclan in doses of 0.5-15 mg/kg inhibited platelet aggregation in vivo. Doses of 20 mg/kg or above showed some hemolytic effect, no other undesirable effects were seen.
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