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. 1976;7(6):439-47.

Study of platelet aggregation in vivo i. Effect of bencyclan

J L Ambrus, C M Ambrus, H Gastpar, P J Sapvento, F J Weber, L E Thurber
  • PMID: 827596

Study of platelet aggregation in vivo i. Effect of bencyclan

J L Ambrus et al. J Med. 1976.

Abstract

A 20mu diameter pore size screen was inserted into an arterio-venous bypass system in heparinized stumptailed monkeys. ADP and serotonin injection resulted in aggregation of platelets on the screen and consecutive increase in pre-screen pressure and decrease in post-screen pressure. From these changes an "aggregation index" was calculated. Bencyclan in doses of 0.5-15 mg/kg inhibited platelet aggregation in vivo. Doses of 20 mg/kg or above showed some hemolytic effect, no other undesirable effects were seen.

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