Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1993;45(3):217-20.
doi: 10.1007/BF00315386.

The effect of prostaglandin E1 during cardiopulmonary bypass on renal function after cardiac surgery

K Abe  1 , Y Fujino, T Sakakibara
Affiliations
Clinical Trial

The effect of prostaglandin E1 during cardiopulmonary bypass on renal function after cardiac surgery

K Abe et al. Eur J Clin Pharmacol. 1993.

Abstract

We have evaluated the effect of prostaglandin E1 (PGE1) on renal function after cardiac surgery with cardiopulmonary bypass in 20 patients, ten of whom received 0.02 microgram.kg-1.min-1 of PGE1 by infusion into the oxygenator during bypass; ten patients served as controls. Serum beta 2-microglobulin fell significantly and urine beta 2-microglobulin increased significantly after surgery in both groups. Urine N-acetyl-beta-D-glucosaminidase was high after surgery in both groups, but it was significantly lower in the PGE1 group. Free water clearance fell significantly on the 1st, 3rd, and 5th postoperative days compared with preoperative values in the control but not in the PGE1 group. These results suggest that PGE1 may prevent renal dysfunction after cardiopulmonary bypass.

PubMed Disclaimer

References

    1. Scand J Clin Lab Invest. 1977 Oct;37(6):477-86 - PubMed
    1. Ann Thorac Surg. 1981 Feb;31(2):121-33 - PubMed
    1. Jpn J Surg. 1982;12(1):19-25 - PubMed
    1. Crit Care Med. 1988 Nov;16(11):1106-9 - PubMed
    1. Lancet. 1973 Jan 20;1(7795):155-6 - PubMed

LinkOut - more resources