Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Nov;84(11):1106-9.
doi: 10.1111/j.1349-7006.1993.tb02808.x.

A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat

O Hino  1 , H Mitani, M Nishizawa, H Katsuyama, E Kobayashi, Y Hirayama
Affiliations

A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat

O Hino et al. Jpn J Cancer Res. 1993 Nov.

Abstract

Hereditary renal cell carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that this predisposing inherited gene is a tumor suppressor gene fitting Knudson's "two-hit" model. This study was designed to map the RC susceptibility gene in the Eker rat using backcross animals. Our present data clearly show that the RC gene is genetically linked to the protamine-1 gene (Lod score = 11.65) and the interleukin-3 gene (Lod score = 4.13), both of which are located on the proximal part of rat chromosome 10. Rat chromosome 10 is currently believed to have no syntenic relationship to human chromosome 3p, the presumed site of the putative tumor suppressor gene for human RC and the locus of von Hippel Lindau disease (affected patients develop multiple RCs). Thus, the Eker rat might have a mutation of a novel tumor suppressor gene related to renal carcinogenesis.

PubMed Disclaimer

References

    1. ) Knudson , A. G.Hereditary cancer, oncogenes and antioncogenes . Cancer Res. , 45 , 1437 – 1443 ( 1985. ). - PubMed
    1. ) Eker , R. and Mossige , J.A dominant gene for renal adenomas in the rat . Nature , 189 , 858 – 859 ( 1961. ).
    1. ) Hino , O. , Klein‐Szanto , A. J. P. , Freed , J. J. , Testa , J. R. , Brown , D. Q. , Vilensky , M. , Yeung , R. S. , Tartof , K. D. and Knudson , A. G.Spontaneous and radiation‐induced renal tumors in the Eker rat model of dominantly inherited cancer . Proc. Natl. Acad. Sci. USA , 90 , 327 – 331 ( 1993. ). - PMC - PubMed
    1. ) Hino , O. , Mitani , H. and Knudson , A. G.High susceptibility of the Eker rat to renal cell tumors (adult type) induction by transplacental administration of N‐ethyl‐N‐nitrosourea . Proc. Am. Assoc. Cancer Res. , 34 , 143 ( 1993. ).
    1. ) Hino , O. , Kitagawa , T. and Sugano , H.Relationship between serum and histochemical markers for hepatitis B virus and rate of viral integration in hepatocellular carcinoma in Japan . Int. J. Cancer , 35 , 5 – 10 ( 1985. ). - PubMed

Publication types

LinkOut - more resources