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. 1993 Dec;123(6 Pt 2):1727-34.
doi: 10.1083/jcb.123.6.1727.

zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly

O Kuge  1 , S Hara-Kuge, L Orci, M Ravazzola, M Amherdt, G Tanigawa, F T Wieland, J E Rothman
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zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly

O Kuge et al. J Cell Biol. 1993 Dec.

Abstract

cDNA encoding the 20-kD subunit of coatomer, zeta-COP, predicts a protein of 177-amino acid residues, similar in sequence to AP17 and AP19, subunits of the clathrin adaptor complexes. Polyclonal antibody directed to zeta-COP blocks the binding of coatomer to Golgi membranes and prevents the assembly of COP-coated vesicles on Golgi cisternae. Unlike other coatomer subunits (beta-, beta'-, gamma-, and epsilon-COP), zeta-COP exists in both coatomer bound and free pools.

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