doi: 10.1038/264722a0.
Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens
- PMID: 827710
- DOI: 10.1038/264722a0
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Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens
Nature.
1976 Dec.
Abstract
The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.
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