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. 1976 Dec;264(5588):722-7.
doi: 10.1038/264722a0.

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

N Bouck, G di Mayorca

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

N Bouck et al. Nature. 1976 Dec.

Abstract

The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.

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