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. 1994;134(1-2):169-78.
doi: 10.1007/BF01379115.

Inter- and intra-strain genomic variation in equine herpesvirus type 1 isolates

W A Bonass  1 , W A Hudson, D M Elton, R A Killington, I W Halliburton
Affiliations

Inter- and intra-strain genomic variation in equine herpesvirus type 1 isolates

W A Bonass et al. Arch Virol. 1994.

Abstract

Restriction enzyme digests of DNA from 22 unselected isolates of EHV-1 were analysed by hybridization with cloned DNA fragments covering the genome. In addition to a small amount of inter-strain variation, heterogeneity within strains was observed, caused by loss of specific restriction endonuclease sites in the DNA of a proportion of the virus particles of any one stock. Fifteen strains demonstrated the same intra-strain variation involving loss of the BamHI L-M site which was shown to lie within coding sequence for the large subunit of ribonucleotide reductase. This particular mutation may therefore be selected for by passage in RK13 cells.

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References

    1. Virus Res. 1990 Feb;15(2):149-61 - PubMed
    1. Arch Virol. 1986;91(3-4):375-81 - PubMed
    1. Microbiologica. 1986 Apr;9(2):221-34 - PubMed
    1. Am J Vet Res. 1991 Aug;52(8):1252-7 - PubMed
    1. Virology. 1992 Jul;189(1):304-16 - PubMed

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