Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies
- PMID: 8279954
- DOI: 10.1007/BF01379116
Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies
Abstract
In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic neutralizing effect on HIV infection. However, sCD4 and an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.
Similar articles
-
Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site.J Virol. 1996 Jul;70(7):4466-73. doi: 10.1128/JVI.70.7.4466-4473.1996. J Virol. 1996. PMID: 8676471 Free PMC article.
-
Identification of an N-linked glycan in the V1-loop of HIV-1 gp120 influencing neutralization by anti-V3 antibodies and soluble CD4.Arch Virol. 1994;139(3-4):253-61. doi: 10.1007/BF01310789. Arch Virol. 1994. PMID: 7832633
-
Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoprotein.J Acquir Immune Defic Syndr (1988). 1992;5(6):591-9. J Acquir Immune Defic Syndr (1988). 1992. PMID: 1588493
-
Antiviral effects of CD4 derivatives.Curr Opin Immunol. 1989-1990 Feb;2(3):433-8. doi: 10.1016/0952-7915(89)90156-8. Curr Opin Immunol. 1989. PMID: 2576772 Review. No abstract available.
-
The auto-regulation model: a unified concept of how HIV regulates its infectivity, pathogenesis and persistence.Int Rev Immunol. 1992;8(1):1-32. doi: 10.3109/08830189209056638. Int Rev Immunol. 1992. PMID: 1573317 Review.
Cited by
-
Neutralization interfering antibodies: a "novel" example of humoral immune dysfunction facilitating viral escape?Viruses. 2012 Sep;4(9):1731-52. doi: 10.3390/v4091731. Epub 2012 Sep 24. Viruses. 2012. PMID: 23170181 Free PMC article. Review.
-
Multiantibody strategies for HIV.Clin Dev Immunol. 2013;2013:632893. doi: 10.1155/2013/632893. Epub 2013 Jun 6. Clin Dev Immunol. 2013. PMID: 23840243 Free PMC article. Review.
-
Additive effects characterize the interaction of antibodies involved in neutralization of the primary dualtropic human immunodeficiency virus type 1 isolate 89.6.J Virol. 2001 Oct;75(19):9177-86. doi: 10.1128/JVI.75.19.9177-9186.2001. J Virol. 2001. PMID: 11533181 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials