VIP gene expression in rat thymus and spleen
- PMID: 8280921
- DOI: 10.1006/brbi.1993.1027
VIP gene expression in rat thymus and spleen
Abstract
Vasoactive intestinal peptide (VIP) is a neuropeptide with immunomodulatory properties. In the present study, we demonstrate VIP gene expression in cells of both thymus and spleen in the rat by in situ hybridization. In thymus sections, hybridization signal for VIP mRNA was found in cells in corticomedullary and medulla regions. In the spleen, cells were labeled at the outer area on the periarteriolar lymphoid sheath of the white pulp. Hybridization signal appeared to be in lymphoid cells. These findings suggest that lymphoid cells might produce VIP, which, if released, could exert a paracrine action on central and peripheral lymphoid organs. We suggest that VIP participates in the bidirectional communication between the nervous and the immune systems.
Similar articles
-
Localization of corticotropin-releasing factor in primary and secondary lymphoid organs of the rat.Brain Behav Immun. 1998 Jun;12(2):107-22. doi: 10.1006/brbi.1998.0520. Brain Behav Immun. 1998. PMID: 9646936
-
Disruption of the optic pathway during development affects vasoactive intestinal peptide mRNA expression.New Biol. 1989 Nov;1(2):215-21. New Biol. 1989. PMID: 2488706
-
Gene expression of VIP receptor in rat lymphocytes.Biochem Biophys Res Commun. 1994 Sep 30;203(3):1599-604. doi: 10.1006/bbrc.1994.2369. Biochem Biophys Res Commun. 1994. PMID: 7945310
-
Vasoactive intestinal peptide in thymus: synthesis, receptors and biological actions.Neuroimmunomodulation. 1999 Jan-Apr;6(1-2):97-107. doi: 10.1159/000026369. Neuroimmunomodulation. 1999. PMID: 9876240 Review.
-
Expression of vasoactive intestinal peptide in lymphocytes: a possible endogenous role in the regulation of the immune system.Adv Neuroimmunol. 1996;6(1):29-36. doi: 10.1016/s0960-5428(96)00001-0. Adv Neuroimmunol. 1996. PMID: 8790779 Review.
Cited by
-
Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients.Blood. 2013 Mar 21;121(12):2347-51. doi: 10.1182/blood-2012-06-437640. Epub 2013 Jan 16. Blood. 2013. PMID: 23325838 Free PMC article.
-
Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.ASN Neuro. 2011 Oct 6;3(4):e00065. doi: 10.1042/AN20110024. ASN Neuro. 2011. PMID: 21895607 Free PMC article. Review.
-
Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice.J Immunol. 2011 Jul 15;187(2):1057-65. doi: 10.4049/jimmunol.1100686. Epub 2011 Jun 15. J Immunol. 2011. PMID: 21677142 Free PMC article.
-
VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair.Br J Pharmacol. 2013 Jun;169(3):512-23. doi: 10.1111/bph.12181. Br J Pharmacol. 2013. PMID: 23517078 Free PMC article. Review.
-
Regulation of VIP gene expression in general. Human lung cancer cells in particular.J Mol Neurosci. 1996 Summer;7(2):99-110. doi: 10.1007/BF02736790. J Mol Neurosci. 1996. PMID: 8873894 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
