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. 1993 Oct;16(10):1051-3.
doi: 10.1248/bpb.16.1051.

Direct determination of opium alkaloid-bovine serum albumin conjugate by matrix-assisted laser desorption/ionization mass spectrometry

Y Shoyama  1 , T Fukada, T Tanaka, A Kusai, K Nojima
Affiliations
Free article

Direct determination of opium alkaloid-bovine serum albumin conjugate by matrix-assisted laser desorption/ionization mass spectrometry

Y Shoyama et al. Biol Pharm Bull. 1993 Oct.
Free article

Abstract

Opium alkaloids (thebaine, codeine and morphine) have been conjugated with bovine serum albumin (BSA) to give individual antigen conjugates which are analyzed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. It became clear that 9 molecules of thebaine were contained in a thebaine-BSA conjugate. Codeine and morphine contents in individual conjugates were determined to be 12 and 6 molecules, respectively.

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