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. 1994 Jan;95(1):56-9.
doi: 10.1111/j.1365-2249.1994.tb06014.x.

Uveitis and anti-neutrophil cytoplasmic antibodies

E C Hagen  1 , H van de Vijver-Reenalda, R J de Keizer, A Kijlstra, L A van Es, M R Daha, F J van der Woude
Affiliations

Uveitis and anti-neutrophil cytoplasmic antibodies

E C Hagen et al. Clin Exp Immunol. 1994 Jan.

Abstract

Serum samples of 485 uveitis patients were screened for the presence of anti-neutrophil cytoplasmic antibodies using a standardized immunofluorescence test (IIF) on neutrophil granulocytes. Seventeen of these sera contained cytoplasmic (C)-ANCA antibodies, while two of the sera contained perinuclear (P)-ANCA antibodies (both antinuclear antibody (ANA)-positive, one anti-myeloperoxidase (MPO)-positive). None of the C-ANCA-positive sera reacted with proteinase-3 in ELISA using a highly purified proteinase-3 preparation. Four C-ANCA and one P-ANCA-positive serum reacted with MPO. The majority of the sera did react with azurophilic granules in ELISA. The implication of these results is that in patients with uveitis a positive C-ANCA test is not diagnostic for Wegener's granulomatosis, but is most probably caused by the presence of autoantibodies against as yet unknown constituents of azurophilic granules.

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