Review
doi: 10.1016/0020-711x(93)90508-c.
Homopurine/homopyrimidine sequences as potential regulatory elements in eukaryotic cells
Affiliations
- PMID: 8288020
- DOI: 10.1016/0020-711x(93)90508-c
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Review
Homopurine/homopyrimidine sequences as potential regulatory elements in eukaryotic cells
Int J Biochem.
1993 Nov.
Abstract
1. Homopurine/homopyrimidine (PuPy) repetitive duplex sequences can form intramolecular triplexes (H-DNA) or intermolecular triplexes with a third strand in a sequence-specific manner. 2. Such sequences are present in natural genomes within 5'- and 3'-flanking sequences and coding regions of genes. Triplex DNA structures have been detected in vitro and in vivo and have been immunolocalized to chromosomes by triplex-specific monoclonal antibody approaches. 3. Intermolecular triplex formation represses gene expression at the transcriptional level and is also useful in genomic mapping, gene cloning, sequence-specific drug delivery, and selective modulation of gene expression.
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