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. 1993 Nov;25(11):1631-5.
doi: 10.1016/0020-711x(93)90522-g.

Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells

K Iwami  1 , T Moriyama
Affiliations

Effects of short chain fatty acid, sodium butyrate, on osteoblastic cells and osteoclastic cells

K Iwami et al. Int J Biochem. 1993 Nov.

Abstract

1. Sodium butyrate increased alkaline phosphatase (ALP) activity of cloned osteoblastic cell line MC3T3-E1 by the stimulation of de novo enzyme synthesis. 2. Sodium butyrate did not affect mature osteoblastic cells but affected preosteoblastic cells. 3. Sodium butyrate decreased tartrate resistant acid phosphatase (TRACP)-positive multinucleated cells (MNC) formation from bone marrow cells. This related to the cytotoxicity of sodium butyrate on bone marrow cells.

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