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. 1994 Jan 18;91(2):709-13.
doi: 10.1073/pnas.91.2.709.

Function of a human cyclin gene as an oncogene

P W Hinds  1 , S F Dowdy, E N Eaton, A Arnold, R A Weinberg
Affiliations

Function of a human cyclin gene as an oncogene

P W Hinds et al. Proc Natl Acad Sci U S A. .

Abstract

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.

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