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Case Reports
. 1993;423(6):507-11.
doi: 10.1007/BF01606543.

Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies

E Condom  1 , A Vidal, R Rota, F Graus, J Dalmau, I Ferrer
Affiliations
Case Reports

Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies

E Condom et al. Virchows Arch A Pathol Anat Histopathol. 1993.

Abstract

Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.

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