[Research on the immunosuppressive activity of rifampicin]

Abstract

The AA. confirm the influence of rifampicin on delayed hypersensitivity phenomena determining its interference on the tuberculin reaction in guinea-pigs sensitized with Freund's adjuvant. In this experimental model rifampicin, either administered during the whole period of sensitization or for shorter periods or even only at the moment of challenge, inhibits the delayed hypersensitivity reactions. Also in man the evolution of citologic reactions connected with PPD stimulation in tuberculous tuberculine-positive patients, studied by the "skin window" method, is modified by a continuous treatment with rifampicin: particularly an inhibition of mononuclear reaction is evident.