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Comparative Study
. 1993 Nov 15;114(1):1-7.
doi: 10.1016/0378-1097(93)90133-m.

Identification and sequence determination of the capsid protein gene of human astrovirus serotype 1

M M Willcocks  1 , M J Carter
Affiliations
Comparative Study

Identification and sequence determination of the capsid protein gene of human astrovirus serotype 1

M M Willcocks et al. FEMS Microbiol Lett. .

Abstract

We present the sequence of an open reading frame (ORF) at the 3' end of human astrovirus serotype 1. Primer extension experiments showed that the RNA expressing this gene is shorter than the complete ORF, and could form a protein of M(r) 85,540. The protein was expressed by recombinant baculovirus and was recognized by anti-virion serum, indicating a structural role. Sequence comparison indicates that astrovirus serotypes 1 and 2 differ markedly in the C-terminal half of the protein but are well conserved towards the N-terminus.

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References

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