Pilot investigation of naproxen/methotrexate interaction in patients with juvenile rheumatoid arthritis
- PMID: 8295192
Pilot investigation of naproxen/methotrexate interaction in patients with juvenile rheumatoid arthritis
Abstract
Objective: To investigate the potential interaction of naproxen and methotrexate (MTX) in children with juvenile rheumatoid arthritis (JRA).
Methods: Nine children with JRA served as their own control taking their usual doses of MTX (0.22-1.02 mg/kg/week) and naproxen (14.6-18.8 mg/kg/day) separately and in combination.
Results: MTX affected a > or = 30% change in naproxen kinetics in 6/8 patients, while naproxen altered MTX kinetics by > or = 30% in 4/9 patients.
Conclusion: MTX can alter nonsteroidal antiinflammatory drug (NSAID) kinetics in children with JRA and NSAID can alter MTX kinetics. NSAID toxicity should be considered when assessing adverse reactions in patients receiving the combination treatment of MTX and NSAID:
Similar articles
-
Methotrexate-nonsteroidal antiinflammatory drug interaction in children with arthritis.J Rheumatol. 1990 Nov;17(11):1469-73. J Rheumatol. 1990. PMID: 2273487
-
Frequency of relapse after discontinuation of methotrexate therapy for clinical remission in juvenile rheumatoid arthritis.J Rheumatol. 1995 Aug;22(8):1574-6. J Rheumatol. 1995. PMID: 7473486
-
Preliminary report of higher dose methotrexate treatment in juvenile rheumatoid arthritis.J Rheumatol. 1992 Oct;19(10):1604-7. J Rheumatol. 1992. PMID: 1464876 Clinical Trial.
-
[Methotrexate and non-steroidal anti-inflammatory agent combination in rheumatoid arthritis].Therapie. 1997 Mar-Apr;52(2):133-7. Therapie. 1997. PMID: 9231508 Review. French.
-
Methotrexate and nonsteroidal antiinflammatory drug interactions.Ann Pharmacother. 1992 Feb;26(2):234-7. doi: 10.1177/106002809202600219. Ann Pharmacother. 1992. PMID: 1554938 Review.
Cited by
-
Clinical pharmacokinetics of naproxen.Clin Pharmacokinet. 1997 Apr;32(4):268-93. doi: 10.2165/00003088-199732040-00002. Clin Pharmacokinet. 1997. PMID: 9113437 Review.
-
Evidence-based use of methotrexate in children with rheumatic diseases: a consensus statement of the Working Groups Pediatric Rheumatology Germany (AGKJR) and Pediatric Rheumatology Austria.Rheumatol Int. 2005 Apr;25(3):169-78. doi: 10.1007/s00296-004-0537-y. Epub 2005 Feb 2. Rheumatol Int. 2005. PMID: 15688190
-
Medical management of children with juvenile rheumatoid arthritis.Drugs. 1999 Nov;58(5):831-50. doi: 10.2165/00003495-199958050-00006. Drugs. 1999. PMID: 10595864 Review.
-
Recommendations for the use of methotrexate in juvenile idiopathic arthritis.Paediatr Drugs. 2006;8(6):347-56. doi: 10.2165/00148581-200608060-00003. Paediatr Drugs. 2006. PMID: 17154642 Review.
-
A clinical approach to the use of methotrexate for sarcoidosis.Thorax. 1999 Aug;54(8):742-6. doi: 10.1136/thx.54.8.742. Thorax. 1999. PMID: 10413729 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Medical