doi: 10.1016/0197-4580(93)90039-e.
DAU 6215, a novel 5-HT3 receptor antagonist, improves performance in the aged rat in the Morris water maze task
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- PMID: 8295658
- DOI: 10.1016/0197-4580(93)90039-e
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DAU 6215, a novel 5-HT3 receptor antagonist, improves performance in the aged rat in the Morris water maze task
Neurobiol Aging.
1993 Nov-Dec.
Abstract
The effects of the new 5-HT3 receptor antagonist, DAU 6215, on aged rats' cognition were assessed in the Morris water maze task. Task performance of aged animals that received acutely the dose of 10 micrograms/kg IP was not different than that of their aged controls treated with the vehicle. Conversely, a repeated IP administration of 10 micrograms/kg DAU 6215 for 3 weeks significantly improved task performance of the aged animals as compared to that displayed by the old rats treated with the vehicle.
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