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. 1994 Feb;151(2):267-70.
doi: 10.1176/ajp.151.2.267.

Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease

A H Miller  1 , G Sastry, A J Speranza Jr, B A Lawlor, R C Mohs, T M Ryan, S M Gabriel, M Serby, J Schmeidler, K L Davis
Affiliations

Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease

A H Miller et al. Am J Psychiatry. 1994 Feb.

Abstract

Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.

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