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Clinical Trial
. 1993 Nov;40(5):625-7.

Disodium-ethylene diamine tetraacetic acid (EDTA) has no effect on blood lipids in atherosclerotic patients. A randomized, placebo-controlled study

B Guldager  1 , O Faergeman, S J Jørgensen, E Nexø, R Jelnes
Affiliations
  • PMID: 8299405
Clinical Trial

Disodium-ethylene diamine tetraacetic acid (EDTA) has no effect on blood lipids in atherosclerotic patients. A randomized, placebo-controlled study

B Guldager et al. Dan Med Bull. 1993 Nov.

Abstract

Objective: To study whether intravenous disodium-ethylene diamine tetraacetic acid (EDTA) affects blood lipids in patients with intermittent claudication.

Design: Double-blind, randomized, placebo-controlled trial.

Participants: Twenty-nine patients with intermittent claudication (systolic ankle-brachial blood pressure index < 0.8; pain free walking distance 50-200 m).

Intervention: 3 g EDTA or placebo (isotonic saline) per infusion over a period of 5-9 weeks to a total of 57 g EDTA. Patients received vitamins, minerals and trace-elements daily.

Results: 14 patients received EDTA and 15 placebo. There was no statistically significant difference in the plasma concentration of cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or triglyceride between the 2 groups.

Conclusion: Treatment with EDTA does not alter blood lipids in patients with intermittent claudication.

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