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. 1994 Feb;62(2):757-8.
doi: 10.1128/iai.62.2.757-758.1994.

Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis

J Hill  1 , P W Andrew, T J Mitchell
Affiliations

Amino acids in pneumolysin important for hemolytic activity identified by random mutagenesis

J Hill et al. Infect Immun. 1994 Feb.

Abstract

The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region of the toxin that affect cytolytic activity.

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