Clinical Trial
Perioperative prophylactic cephazolin in spinal surgery. A double-blind placebo-controlled trial
Affiliations
- PMID: 8300691
Item in Clipboard
Clinical Trial
Perioperative prophylactic cephazolin in spinal surgery. A double-blind placebo-controlled trial
J Bone Joint Surg Br.
1994 Jan.
Abstract
We investigated the efficacy of a single dose of 1 g of cephazolin in reducing postoperative infections in patients undergoing 'clean' operations on the lumbar spine. In a double-blind, randomised, trial there were 21 wound or urinary infections in the 71 patients who received placebo and nine in the 70 who received cephazolin (p < 0.05). Nine of the placebo patients (12.7%) developed wound infections (complicated by bacteraemia in two) compared with three (4.3%) in the cephazolin group (p = 0.07). Hospital stay was longer for infected patients than for non-infected patients (p < 0.05). Cephazolin-resistant pathogens were isolated more frequently from patients who received cephazolin than from those who received placebo.
Similar articles
-
[Antibiotic prophylaxis in colon surgery: cefazolin (Kefzol- ornidazole (Tiberal) versus cephazolin-placebo].Helv Chir Acta. 1989 Jun;56(1-2):211-5. Helv Chir Acta. 1989. PMID: 2674063 Clinical Trial. German.
-
Piperacillin versus cefazolin given perioperatively to high-risk patients who undergo open cholecystectomy: a double-blind, randomized trial.Can J Surg. 1993 Jun;36(3):245-50. Can J Surg. 1993. PMID: 8324671 Clinical Trial.
-
Perioperative cefazolin prophylaxis in hip fracture surgery.Can J Surg. 1990 Apr;33(2):122-7. Can J Surg. 1990. PMID: 2268811 Clinical Trial.
-
A double-blinded, randomized, controlled clinical trial to compare cefazolin and cefonicid for antimicrobial prophylaxis in clean orthopedic surgery.Isr J Med Sci. 1995 Jan;31(1):62-4. Isr J Med Sci. 1995. PMID: 7836052 Clinical Trial.
-
A prospective, randomized double-blind study of the use of antibiotics at the time of mastectomy.Surg Gynecol Obstet. 1990 Jan;170(1):12-6. Surg Gynecol Obstet. 1990. PMID: 2403697 Clinical Trial.
Cited by
-
The combined administration of vancomycin IV, standard prophylactic antibiotics, and vancomycin powder in spinal instrumentation surgery: does the routine use affect infection rates and bacterial resistance?J Spine Surg. 2018 Jun;4(2):173-179. doi: 10.21037/jss.2018.05.04. J Spine Surg. 2018. PMID: 30069504 Free PMC article.
-
Surgical site infection in spinal surgery: a comparative study between 2-octyl-cyanoacrylate and staples for wound closure.Eur Spine J. 2014 Apr;23(4):854-62. doi: 10.1007/s00586-014-3202-5. Epub 2014 Feb 1. Eur Spine J. 2014. PMID: 24487558 Free PMC article. Clinical Trial.
-
Vancomycin Antibiotic Prophylaxis Compared to Cefazolin Increases Risk of Surgical Site Infection Following Spine Surgery.Global Spine J. 2025 May 7:21925682251341833. doi: 10.1177/21925682251341833. Online ahead of print. Global Spine J. 2025. PMID: 40336255 Free PMC article.
-
Perioperative antibiotic prophylaxis in spinal surgery.SICOT J. 2021;7:31. doi: 10.1051/sicotj/2021029. Epub 2021 May 10. SICOT J. 2021. PMID: 33973847 Free PMC article.
-
Effectiveness of topical vancomycin in the prevention of spinal surgical site infections: a retrospective cohort study.Antimicrob Resist Infect Control. 2021 Sep 26;10(1):136. doi: 10.1186/s13756-021-01006-6. Antimicrob Resist Infect Control. 2021. PMID: 34565484 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical