. 1993 Sep;9(5):341-6; discussion 346-7.
doi: 10.1055/s-2007-1006741.
Sciatic nerve regeneration across gaps within collagen chambers: the influence of epidermal growth factor
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- PMID: 8301632
- DOI: 10.1055/s-2007-1006741
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Sciatic nerve regeneration across gaps within collagen chambers: the influence of epidermal growth factor
J Reconstr Microsurg.
1993 Sep.
Abstract
The effects of Epidermal Growth Factor (EGF) on axonal regeneration of a sectioned sciatic nerve within collagen tubes were investigated in 15 rats. Following baseline electrophysiologic assessment, bilateral 7-mm nerve gaps were created and repaired by interposition of collagen tubes, into which EGF (left side) or type I collagen (right side) was instilled. After 4 or 8 weeks, axonal regeneration, measured by electrophysiologic and histologic means, was identical for the EGF and control legs. The conclusion is that EGF does not influence nerve regeneration within a collagen chamber.
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