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Comparative Study
. 1993 Sep;123(3):135-40.
doi: 10.1007/BF01111263.

Comparative efficacy of amphotericin B, clotrimazole and itraconazole against Aspergillus spp. An in vitro study

Y H Hahn  1 , D G Ahearn, L A Wilson
Affiliations
Comparative Study

Comparative efficacy of amphotericin B, clotrimazole and itraconazole against Aspergillus spp. An in vitro study

Y H Hahn et al. Mycopathologia. 1993 Sep.

Abstract

The susceptibilities of two isolates of Aspergillus flavus, one from a human case of recalcitrant mycotic keratitis, and an environmental isolate of A. fumigatus, to itraconazole, clotrimazole and amphotericin B were measured. Observations of macroscopic growth and microscopic evaluations of conidia germination both indicated that the two isolates of A. flavus were markedly more resistant to amphotericin B than to itraconazole and clotrimazole. Itraconazole was more effective than clotrimazole for all isolates. Our in vitro susceptibility results suggest the use of itraconazole should be a primary consideration in the treatment of Aspergillus keratitis.

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