Review
doi: 10.1111/j.1753-4887.1993.tb03062.x.
Interleukin-2 production is altered by copper deficiency
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- PMID: 8302489
- DOI: 10.1111/j.1753-4887.1993.tb03062.x
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Review
Interleukin-2 production is altered by copper deficiency
Nutr Rev.
1993 Oct.
Abstract
Copper is an essential nutrient for optimal function of the immune system; deficiency results in impairment of both humoral and cell-mediated components. Copper deficiency in rodents results in decreased numbers of CD4+ (helper) and total T cells. This defect has been traced to impaired production of interleukin-2, a cytokine essential for T-cell division and differentiation. Impairment of quiescent cell proliferation is reversed by both in vivo and in vitro copper supplementation.
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