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Clinical Trial
. 1993;124(2-4):114-9.
doi: 10.1007/BF01401132.

The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia

K Jensen  1 , M Freundlich, L Bünemann, K Therkelsen, H Hansen, G E Cold
Affiliations
Clinical Trial

The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia

K Jensen et al. Acta Neurochir (Wien). 1993.

Abstract

In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2-4% CO2 normalized CBF.

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References

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