Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review

Abstract

The glutathione S-transferases are a major group of soluble liver proteins that are involved in the cellular detoxification of electrophilic compounds. Several of these transferases, in particular glutathione S-transferase B or ligandin, interact with chemical carcinogens in vivo. This review presents evidence that ligandin and the other glutathione S-transferases reduce the susceptibility of the liver to aminoazo dye-, polycyclic aromatic hydrocarbon-, and aromatic amine-induced carcinogenesis. Several possible mechanisms by which the transferases reduce hepatocarcinogenesis are proposed. These mechanisms include the direct binding and detoxification of carcinogens by the transferases and the inctivation of steroids and other agents that indirectly stimulate carcinogen activation.