Review
doi: 10.1006/scel.1993.1049.
The leukocyte common antigen, CD45 and other protein tyrosine phosphatases in hematopoietic cells
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- PMID: 8305680
- DOI: 10.1006/scel.1993.1049
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Review
The leukocyte common antigen, CD45 and other protein tyrosine phosphatases in hematopoietic cells
Semin Cell Biol.
1993 Dec.
Abstract
Numerous protein tyrosine phosphatases have been characterized that are expressed by hematopoietic-derived cells. CD45, a transmembrane protein tyrosine phosphatase expressed by all nucleated cells of hematopoietic origin, has been a prototype for studying the function of these enzymes. In T lymphocytes, CD45 serves to dephosphorylate and activate members of the Src-tyrosine kinase family. Without CD45 function, T cells cannot respond to antigen. Therefore, CD45 functions positively to regulate lymphocyte activation. The characteristics of other protein tyrosine phosphatases found in hematopoietic-derived cells suggests that they are also essential in regulating cell differentiation and activation.
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