Hereditary papillary renal cell carcinoma
- PMID: 8308957
- DOI: 10.1016/s0022-5347(17)35015-2
Hereditary papillary renal cell carcinoma
Abstract
We describe a 3 generation family with members affected with papillary renal cell carcinoma, an uncommon histological type of renal cell carcinoma. Multiple tumors of varying size were present in both kidneys of affected family members. The disorder was not linked to polymorphic markers on chromosome 3p and there was no loss of heterozygosity at loci on 3p in renal tumors. The results suggest the presence of a renal cell carcinoma gene not located on 3p that predisposes to renal cell carcinoma with a distinct histological appearance. The inherited disorder in this family appears to be different from recognized hereditary cancer syndromes.
Comment in
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Re: Hereditary papillary renal cell carcinoma: clinical studies in 10 families.J Urol. 1996 Nov;156(5):1781. doi: 10.1016/s0022-5347(01)65520-4. J Urol. 1996. PMID: 8863608 No abstract available.
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