doi: 10.1016/0091-3057(93)90228-l.
Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat
Affiliations
- PMID: 8309976
- DOI: 10.1016/0091-3057(93)90228-l
Item in Clipboard
Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat
Pharmacol Biochem Behav.
1993 Dec.
Abstract
Animals administered the nitric oxide (NO) synthase inhibitor N-w-nitro-L-arginine methyl ester (NAME) for five days exhibited severe deficits in acquisition of a place-navigation learning task. The effect of NAME was selective to place-navigation learning. NAME had no effect on sensorimotor or motivational processes in a related task. These results are consistent with the view that NO participates in learning and execution of memory tasks.
Similar articles
-
Inhibition of nitric oxide synthesis impairs two different forms of learning.Neuroreport. 1992 Jul;3(7):567-70. doi: 10.1097/00001756-199207000-00005. Neuroreport. 1992. PMID: 1421108
-
Effects of nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on spatial and cued leaning.Neuroscience. 1998 Apr;83(3):837-41. doi: 10.1016/s0306-4522(97)00457-0. Neuroscience. 1998. PMID: 9483567
-
Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain.Br J Pharmacol. 1995 Jul;115(5):852-8. doi: 10.1111/j.1476-5381.1995.tb15011.x. Br J Pharmacol. 1995. PMID: 8548187 Free PMC article.
-
Inhibition of nitric oxide synthase does not impair spatial learning.J Neurosci. 1994 Dec;14(12):7404-14. doi: 10.1523/JNEUROSCI.14-12-07404.1994. J Neurosci. 1994. PMID: 7527842 Free PMC article.
-
Dissociating learning and performance: drug and hormone enhancement of memory storage.Brain Res Bull. 1989 Oct-Nov;23(4-5):339-45. doi: 10.1016/0361-9230(89)90220-7. Brain Res Bull. 1989. PMID: 2574071 Review.
Cited by
-
Memory-specific temporal profiles of gene expression in the hippocampus.Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16279-84. doi: 10.1073/pnas.242597199. Epub 2002 Dec 2. Proc Natl Acad Sci U S A. 2002. PMID: 12461180 Free PMC article.
-
7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice.Drug Target Insights. 2015 Mar 4;9:1-8. doi: 10.4137/DTI.S23378. eCollection 2015. Drug Target Insights. 2015. PMID: 25788830 Free PMC article.
-
Nitric oxide is involved in the memory facilitation induced by spermidine in rats.Psychopharmacology (Berl). 2006 Jun;186(2):150-8. doi: 10.1007/s00213-006-0376-5. Epub 2006 Apr 7. Psychopharmacology (Berl). 2006. PMID: 16601997
-
Nitric Oxide Synthase Inhibitors as Antidepressants.Pharmaceuticals (Basel). 2010 Jan 20;3(1):273-299. doi: 10.3390/ph3010273. Pharmaceuticals (Basel). 2010. PMID: 27713253 Free PMC article. Review.
-
Nitric oxide modulates the release of acetylcholine in the ventral striatum of the freely moving rat.Naunyn Schmiedebergs Arch Pharmacol. 1995 Jul;352(1):67-73. doi: 10.1007/BF00169191. Naunyn Schmiedebergs Arch Pharmacol. 1995. PMID: 7477427
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
