Clinical Trial
doi: 10.1111/j.1600-0447.1993.tb03487.x.
A double-blind study of L-sulpiride versus amitriptyline in lithium-maintained bipolar depressives
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- PMID: 8310852
- DOI: 10.1111/j.1600-0447.1993.tb03487.x
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Clinical Trial
A double-blind study of L-sulpiride versus amitriptyline in lithium-maintained bipolar depressives
Acta Psychiatr Scand.
1993 Dec.
Abstract
A double-blind group comparison study of L-sulpiride and amitriptyline was carried out in 30 bipolar outpatients on maintenance treatment with lithium suffering from a major depressive recurrence. L-sulpiride showed equivalent antidepressant activity to amitriptyline at 4 weeks using the Hamilton Rating Scale for Depression. However, the onset of action was faster in the L-sulpiride group, showing a significant improvement at 1 week in both anxiety-somatization and specific depression items, including depressed mood, feelings of guilt, work & activities and retardation. The incidence of anticholinergic side effects was significantly higher in the amitriptyline treatment group.
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