Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1994 Jan;53(1):14-7.
doi: 10.1136/ard.53.1.14.

Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis

A K Gough  1 , N F Peel, R Eastell, R L Holder, J Lilley, P Emery
Affiliations
Comparative Study

Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis

A K Gough et al. Ann Rheum Dis. 1994 Jan.

Abstract

Objective: To establish if urinary excretion rates of the collagen crosslinks pyridinoline and deoxypyridinoline, which are known to be elevated in established rheumatoid arthritis (RA), are useful markers of bone loss in this disease.

Methods: Eight hour urine collections on all patients and 52 controls were performed, and the rates of pyridinoline and deoxypyridinoline excretion were measured. Bone mineral density (BMD), by dual energy x-ray absorption, and full laboratory and clinical assessments were performed.

Results: The rates of excretion of pyridinoline and deoxypyridinoline were significantly increased in patients compared with controls (p < 0.001). Pyridinoline excretion was associated with increased disease activity (ESR/CRP) but not disability (HAQ score/Functional Grade), and correlated with BMD loss at the femoral neck (p < 0.01).

Conclusion: The excretion of collagen crosslinks may be useful as markers of bone and cartilage turnover in patients with RA.

PubMed Disclaimer

References

    1. Ann Rheum Dis. 1965 May;24:219-23 - PubMed
    1. Bull Rheum Dis. 1960 Nov;11:231-4 - PubMed
    1. Acta Rheumatol Scand. 1968;14(4):276-84 - PubMed
    1. Calcif Tissue Res. 1970;5(4):327-32 - PubMed
    1. Rheumatol Rehabil. 1978 May;17(2):65-71 - PubMed

Publication types