doi: 10.1126/science.831259.
Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens
- PMID: 831259
- DOI: 10.1126/science.831259
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Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens
Science.
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Abstract
The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.
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