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. 1994 Feb;15(2):159-61.
doi: 10.1093/carcin/15.2.159.

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

P P Fu  1 , K L Dooley, L S Von Tungeln, T Bucci, R W Hart, F F Kadlubar
Affiliations

Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice

P P Fu et al. Carcinogenesis. 1994 Feb.

Abstract

Caloric restriction (CR) inhibited strongly the incidence of chemically-induced tumors in the neonatal B6C3F1 mouse tumorigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. These data indicate that CR can have a profound inhibitory effect on tumor development even long after metabolic activation and DNA repair have occurred.

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