Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Mar;43(3):500-4.
doi: 10.2337/diab.43.3.500.

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

L S Wicker  1 , E H Leiter, J A Todd, R J Renjilian, E Peterson, P A Fischer, P L Podolin, M Zijlstra, R Jaenisch, L B Peterson
Affiliations

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

L S Wicker et al. Diabetes. 1994 Mar.

Abstract

The role of CD8+ T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4+ T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8+ T-cells are not required for beta-cell destruction. To assess the contribution of CD8+ T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of beta 2-microglobulin (NOD-B2mnull). NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to beta-cells in the NOD mouse.

PubMed Disclaimer

Publication types