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. 1993;10(6):389-94.
doi: 10.1002/gepi.1370100610.

Linkage detection by the Affected-Pedigree-Member method: what is really tested?

M C Babron  1 , M Martinez, C Bonaïti-Pellié, F Clerget-Darpoux
Affiliations

Linkage detection by the Affected-Pedigree-Member method: what is really tested?

M C Babron et al. Genet Epidemiol. 1993.

Abstract

We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.

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