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. 1993 Jun;91(5):464-8.
doi: 10.1007/BF00217773.

Inter-ethnic polymorphism of the beta-globin gene locus control region (LCR) in sickle-cell anemia patients

B Périchon  1 , A Ragusa, C Lapouméroulie, A Romand, P Moi, T Ikuta, D Labie, J Elion, R Krishnamoorthy
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Inter-ethnic polymorphism of the beta-globin gene locus control region (LCR) in sickle-cell anemia patients

B Périchon et al. Hum Genet. 1993 Jun.

Abstract

Sequence polymorphisms within the 5'HS2 segment of human locus control region is described among sickle cell anemia patients. Distinct polymorphic patterns of a simple sequence repeat are observed in strong linkage disequilibrium with each of the five major beta s haplotypes. Potential functional relevance of this polymorphic region in globin gene expression is discussed.

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