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. 1993 May;29A(5):419-26.
doi: 10.1007/BF02633992.

Macrophages release melanocyte dendrite extension factor in response to ultra-violet ray

S Suzuki  1 , T Katagiri, T Takeuchi
Affiliations

Macrophages release melanocyte dendrite extension factor in response to ultra-violet ray

S Suzuki et al. In Vitro Cell Dev Biol Anim. 1993 May.

Abstract

Mammalian melanocytes in epidermis extend their dendrites in response to UV ray in vivo in addition to proliferation and pigmentation. We found that cultured macrophages exert a factor in response to UV irradiation and that this factor induces the extension of dendrites of melanocyte. We designated this factor as dendrite extension factor (DEF) and characterized it as a protein. Our results indicate that the molecular weight of DEF is 30,000-100,000 and that it is heat-labile. Macrophages release DEF through transcription and translation. DEF seems to be a novel factor that enhances melanogenesis by UV irradiation.

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