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. 1993 Jul 2;261(5117):58-65.
doi: 10.1126/science.8316858.

Structure of the actin-myosin complex and its implications for muscle contraction

I Rayment  1 , H M Holden, M Whittaker, C B Yohn, M Lorenz, K C Holmes, R A Milligan
Affiliations

Structure of the actin-myosin complex and its implications for muscle contraction

I Rayment et al. Science. .

Abstract

Muscle contraction consists of a cyclical interaction between myosin and actin driven by the concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F actin and the myosin head was obtained by combining the molecular structures of the individual proteins with the low-resolution electron density maps of the complex derived by cryo-electron microscopy and image analysis. The spatial relation between the ATP binding pocket on myosin and the major contact area on actin suggests a working hypothesis for the crossbridge cycle that is consistent with previous independent structural and biochemical studies.

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Comment in

  • Molecular muscle.
    Taylor EW. Taylor EW. Science. 1993 Jul 2;261(5117):35-6. doi: 10.1126/science.8316856. Science. 1993. PMID: 8316856 No abstract available.

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