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. 1993:38 Spec No:C122-4.
doi: 10.1007/BF01991158.

Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment

F J Zijlstra  1 , A P van Dijk, R J Ouwendijk, I C van Riemsdijk-Overbeeke, J H Wilson
Affiliations

Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment

F J Zijlstra et al. Agents Actions. 1993.

Abstract

Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.

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