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. 1993:38 Spec No:C7-9.
doi: 10.1007/BF01991120.

Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia

S H Ferreira  1 , B B Lorenzetti, F Q Cunha, S Poole
Affiliations

Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia

S H Ferreira et al. Agents Actions. 1993.

Abstract

Using specific antisera for IL-1 beta and IL-8, as well as cyclooxygenase inhibitors and propranolol, we have demonstrated that these cytokines are responsible for the prostaglandin and sympathetic components of carrageenin-induced hyperalgesia in the rat paw test. The release of IL-1 beta and IL-8 is preceded by the liberation of TNF-alpha. We have also tested in a nociceptive model the effects of bradykinin and a specific bradykinin antagonist, HOE 140, on the hyperalgesia induced by carrageenin and lipopolysaccharide (LPS). Bradykinin-induced hyperalgesia was abolished by HOE 140 and by treatment of the paws with anti-TNF-alpha antisera. HOE 140 significantly inhibited the hyperalgesia induced by carrageenin and LPS. It is suggested that in these two models bradykinin is associated with the release of hyperalgesic cytokines.

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