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Comparative Study
. 1993 Jun 25;1173(3):314-9.
doi: 10.1016/0167-4781(93)90129-2.

Cloning and characterization of a bovine alpha interferon receptor

J K Lim  1 , J A Langer
Affiliations
Comparative Study

Cloning and characterization of a bovine alpha interferon receptor

J K Lim et al. Biochim Biophys Acta. .

Abstract

A bovine interferon alpha receptor (BoIFN-alpha R1) cDNA, homologous to the human cDNA, was isolated. Transfection of the BoIFN-alpha R1 cDNA into monkey COS cells results in a large increase in high-affinity binding sites for human IFN-alpha A and IFN-alpha B. Covalent crosslinking of radiolabeled HuIFN-alpha A and -alpha B demonstrates that the complex of [32P]HuIFN with the BoIFN-alpha R1 protein (predicted mass, 61,375) expressed in COS cells migrates as a 140-150 kDa band.

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